August
2005
Dear
Friends
Greetings from Auckland where we are
basking in a mild and beautiful winter...well so far, and today anyway.
I hope this finds you well.
Since last October I have enjoyed
the constant support and friendship of Timra Freedman - a wonderful
wise woman from Boston. Timra is supremely healthy and energetic
and leads a fabulous full life. She exercises every day, has an excellent
diet, and has taken supplemental vitamins and minerals for years.
Timra was given a diagnosis of osteoporosis last year after a bone
mineral density scan. The only fractures she has sustained were the
result of a serious high-impact bike accident in 2001 when a car
wrongly turned across her path. As she says “I certainly don't
think that it had anything to do with the state of my bones at the
time. I just hit her car so hard!” She reluctantly took Fosamax
for 6 months and then Actonel for one month. Both drugs made her
ill.
After reading my book The
Myth of Osteoporosis Timra was
galvanised to promote the issues around the over-diagnosis and
over treatment of osteoporosis and osteopenia in the well. She
has tirelessly contacted U.S. doctors, specialists, organisations,
media, journalists, and individuals. Her Herculean efforts are
bearing fruit. On July 6 my book was very favourably reviewed
in the prestigious Journal
of the American Medical Association (JAMA) and in May was
the impetus for an article by medical journalist Judy
Foreman in the Boston Globe, New York Sun, Baltimore Sun
and the Los Angeles Times. Timra’s perseverance and dedication
prove that one person can make a difference. I am totally indebted
to her.
New ‘must
read’ books:
There are three excellent new books available on the reclassifying of healthy
people as ill and the marketing of potent drugs to prevent conditions that
may never happen or were once categorised as normal. Selling
Sickness – How Drug Companies Are Turning Us All Into Patients by
Ray Moynihan and Alan Cassels, and Overdosed
America: The Broken Promise of American Medicine by John Abramson
M.D. discuss conditions such as hypertension where the goal posts have been
moved to encompass some 50 million Americans; and ‘prehypertension’,
a category that turns previously normal blood pressure levels into a treatable
condition. Cassells and Moynihan describe the gradual blurring of the boundaries
defining normal and abnormal behaviour so that female mood swings can be categorised
as ‘premenstrual dysphoric disorder’ (PMDD), a lowering of libido
in older women ‘female sexual dysfunction’ (FSD), shyness ‘social
phobia’, and being disorganised and distracted ‘adult attention
deficit disorder’ – all conditions that have, of course, a pharmaceutical ‘solution’.
John Abramson reveals the difficulties physicians face when much of the medical
literature they have been trained to believe is accurate and scientific is
little more than cleverly manipulated data designed to market drugs.
The
Myth of Cholesterol:: Dispelling the Fear and Creating Real Heart
Health by Paul Dugliss M.D., and Sandra Fernandez M.S.P.H.,
challenges the established belief that cholesterol plays a major
role in heart disease. Just as osteoporosis has been redefined
to include almost half the adult female population, so has the
threshold been altered for a diagnosis of ‘dangerous’ cholesterol
levels. The official U.S. cholesterol guidelines have been rewritten
several times, increasing the number of people taking statin
drug treatment from 13 million in the 90’s to 40 million
in 2004. What the public aren’t told is that many of the
experts who created the new guidelines were linked to the drug
companies who stood to benefit. Neither do many people know that
studies published in JAMA and the New England Journal of Medicine
show that elevated cholesterol does not significantly increase
a healthy women's risk of heart disease or overall mortality,
and that women who exercise and maintain a healthy diet develop
83 percent less heart disease than those who don't. Remarkably,
not one of the six major clinical studies that the new cholesterol
guidelines are based on provides significant evidence that statins
are beneficial for healthy women.
Bisphosphonate
news:
Last month I wrote about a worrying and largely unacknowledged side-effect
of bisphosphonates – the chronic, often severe, joint and bone pain,
swelling of ankles and feet, muscles cramping and stiffness, and difficulty
walking reported by many women using Fosamax and Actonel. Serendipitously,
the Food and Drug Administration published
correspondence in the Archives of Internal Medicine in February 2005 analysing
over 100 reports of similar physical symptoms described by some consumers as ‘severe’ ‘extreme’ ‘disabling’ or ‘incapacitating’.
The authors comment that the clinical trials leading to the FDA approval of
Fosamax and Actonel did not identify this side-effect, but acknowledge that
previously unknown side-effects can sometimes surface once a drug is out there
in the market place.
This certainly seems to be the case
with bisphosphonates as the list of negative effects grows ever longer.
The FDA
advised dentists and cancer physicians in May 2005 that the labels
or package inserts for the injectable bisphosphonate drugs zoledronic
acid (Zometa) and pamidronate (Aredia) had been revised to warn about
the possibility of osteonecrosis of the jaw with the use of these
drugs. Osteonecrosis literally means “bone death.” There
have also been reports
in the medical literature of osteonecrosis of the jaw associated
with the use of Fosamax and Actonel.
There are concerns that Fosamax might
impair bone healing and that the drug-induced increase in bone minerals
could make bones more brittle. A report in The
Journal of Clinical Endocrinology and Metabolism in March 2005
described nine patients on Fosamax with osteoporosis or osteopenia
who had non-traumatic (low impact) fractures. Six patients continuing
the drug experienced delayed or no healing of broken bones. In her
July 11 New York Times article Postmenopausal Women Face Issues
About Bone Loss journalist Jane
Brody reports on the case of "a healthy active woman, 59,
who after six years on Fosamax for osteopenia in her spine was jolted
on a subway and broke her thigh bone. The injury took two years to
heal, and the healing occurred only after she had stopped taking
Fosamax. A year later, she resumed the drug, only to suffer a non-traumatic
fracture in her foot."
The vast majority who take Fosamax
will receive no benefit. A just-published
review of the data for a range of osteoporosis treatments from
eleven randomised clinical trials of at least 3 years duration failed
to find any non-vertebral fracture benefit at all from Fosamax raising
further questions about its widespread unchecked use.
Our challenge as healthcare consumers
is to find genuinely independent information regarding disease prevention,
the diagnosis of conditions, and the safest most effective methods
of treatment. It can be hard to find, but is increasingly available
as more doctors, journalists and individuals question the over-medicalisation
of ‘worried well’ adult populations and the aggressive
way the pharmaceutical industry is convincing people that drugs are
preferable to time-tested simple lifestyle changes such as eating
well, exercising and quitting smoking.
Wishing you great good health
Gillian
IMPORTANT:
If you have had adverse or severe reactions to any drug you can report this
to the FDA by going to http://www.fda.gov/medwatch/report/consumer/consumer.htm
or by phoning 1(800) FDA-1088.
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